Drug interactions
Chlorothiazide + Dichlorphenamide
Severity: Moderate
Chlorothiazide and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents promote renal potassium loss, so combined use can cause marked hypokalemia. Low potassium raises the risk of muscle weakness and cardiac arrhythmias, and is particularly relevant in patients with periodic paralysis.
What this interaction means in plain words
Chlorothiazide and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive kaliuresis from carbonic anhydrase inhibition and thiazide-induced distal sodium delivery.
What to do
Monitor serum potassium and bicarbonate at baseline and periodically. Give potassium supplementation or adjust therapy if hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Dichlorphenamide?
MediHelp rates the interaction as moderate. Chlorothiazide and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents promote renal potassium loss, so combined use can cause marked hypokalemia. Low potassium raises the risk of muscle weakness and cardiac arrhythmias, and is particularly relevant in patients with periodic paralysis.
How serious is the interaction between Chlorothiazide and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and periodically. Give potassium supplementation or adjust therapy if hypokalemia develops.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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