Drug interactions
Chlorothiazide + Hydrochlorothiazide-olmesartan
Severity: Moderate
Chlorothiazide and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide duplicates the thiazide already present in the combination, increasing the risk of volume depletion, hypotension, hypokalemia, hyponatremia and hyperglycemia. Olmesartan only partly offsets potassium loss.
What this interaction means in plain words
Chlorothiazide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive inhibition of the distal tubular sodium-chloride cotransporter.
What to do
Avoid duplicate thiazide therapy unless intentionally planned, such as for resistant edema. Monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Chlorothiazide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide duplicates the thiazide already present in the combination, increasing the risk of volume depletion, hypotension, hypokalemia, hyponatremia and hyperglycemia. Olmesartan only partly offsets potassium loss.
How serious is the interaction between Chlorothiazide and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate thiazide therapy unless intentionally planned, such as for resistant edema. Monitor electrolytes, renal function and blood pressure.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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