Drug interactions
Chlorothiazide + Indapamide
Severity: Moderate
Chlorothiazide and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two thiazide-type diuretics together provides little added benefit and increases the risk of hypokalemia, hyponatremia, hypomagnesemia and volume depletion.
What this interaction means in plain words
Chlorothiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Both inhibit the distal tubular sodium-chloride cotransporter, giving additive electrolyte loss.
What to do
Avoid duplicate thiazide therapy and choose one agent. If co-administered, monitor sodium, potassium and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Indapamide?
MediHelp rates the interaction as moderate. Chlorothiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two thiazide-type diuretics together provides little added benefit and increases the risk of hypokalemia, hyponatremia, hypomagnesemia and volume depletion.
How serious is the interaction between Chlorothiazide and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate thiazide therapy and choose one agent. If co-administered, monitor sodium, potassium and renal function.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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