Drug interactions
Chlorothiazide + Piperacillin-tazobactam
Severity: Minor
Chlorothiazide and Piperacillin-tazobactam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may modestly reduce renal tubular secretion of penicillins, which could slightly raise piperacillin exposure. The effect is small and rarely clinically relevant.
What this interaction means in plain words
Chlorothiazide and Piperacillin-tazobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Piperacillin-tazobactam belongs to Anti Bacterial.
Why it happens
Competition for renal organic anion tubular secretion may slightly reduce piperacillin clearance.
What to do
No action is usually required; consider the effect only in significantly impaired renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piperacillin-tazobactam
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Piperacillin-tazobactam?
MediHelp rates the interaction as minor. Chlorothiazide and Piperacillin-tazobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics may modestly reduce renal tubular secretion of penicillins, which could slightly raise piperacillin exposure. The effect is small and rarely clinically relevant.
How serious is the interaction between Chlorothiazide and Piperacillin-tazobactam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually required; consider the effect only in significantly impaired renal function.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Vancomycin, Amikacin, Antithrombin alfa. The full list is on the Piperacillin-tazobactam page.
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