Drug interactions
Chlorothiazide + Pirbuterol
Severity: Moderate
Chlorothiazide and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide causes renal potassium loss and pirbuterol can lower serum potassium by driving it into cells. Combined use may cause additive hypokalemia that can promote arrhythmias, particularly in patients with heart disease.
What this interaction means in plain words
Chlorothiazide and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia: thiazide renal potassium wasting plus beta-2 mediated cellular potassium uptake.
What to do
Monitor serum potassium and magnesium, particularly with high or frequent pirbuterol dosing. Supplement potassium when needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Pirbuterol?
MediHelp rates the interaction as moderate. Chlorothiazide and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide causes renal potassium loss and pirbuterol can lower serum potassium by driving it into cells. Combined use may cause additive hypokalemia that can promote arrhythmias, particularly in patients with heart disease.
How serious is the interaction between Chlorothiazide and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly with high or frequent pirbuterol dosing. Supplement potassium when needed.
What other medicines interact with Chlorothiazide?
MediHelp also lists interactions of Chlorothiazide with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Candesartan-hydrochlorothiazide, Hydrochlorothiazide-lisinopril. The full list is on the Chlorothiazide page.
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