Drug interactions
Chlorpheniramine + Dabrafenib
Severity: Minor
Chlorpheniramine and Dabrafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower chlorpheniramine concentrations. Reduced antihistamine effect is possible but typically mild.
What this interaction means in plain words
Chlorpheniramine and Dabrafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpheniramine belongs to Respiratory; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induction of CYP3A4 accelerates chlorpheniramine clearance.
What to do
Monitor symptom control and adjust the chlorpheniramine dose or switch antihistamine if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpheniramine
Other interactions of Dabrafenib
Frequently asked questions
Can I take Chlorpheniramine with Dabrafenib?
MediHelp rates the interaction as minor. Chlorpheniramine and Dabrafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and may lower chlorpheniramine concentrations. Reduced antihistamine effect is possible but typically mild.
How serious is the interaction between Chlorpheniramine and Dabrafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and adjust the chlorpheniramine dose or switch antihistamine if efficacy is lost.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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