Drug interactions
Chlorpheniramine + Esketamine
Severity: Moderate
Chlorpheniramine and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a first-generation antihistamine that commonly causes drowsiness. With esketamine, sedation and psychomotor impairment may be increased.
What this interaction means in plain words
Chlorpheniramine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression from esketamine and central H1 receptor blockade.
What to do
Monitor sedation during and after esketamine sessions. Consider a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Esketamine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a first-generation antihistamine that commonly causes drowsiness. With esketamine, sedation and psychomotor impairment may be increased.
How serious is the interaction between Chlorpheniramine and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation during and after esketamine sessions. Consider a non-sedating antihistamine if one is needed.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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