Drug interactions
Chlorpheniramine + Flurazepam
Severity: Moderate
Chlorpheniramine and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating antihistamine with the long-acting benzodiazepine flurazepam increases drowsiness, dizziness and psychomotor impairment. Because the active metabolite of flurazepam persists, effects may last into the next day, with higher fall risk in older adults.
What this interaction means in plain words
Chlorpheniramine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from H1-receptor blockade and GABA-A receptor potentiation.
What to do
Avoid combining where possible, especially in elderly patients, or use the lowest effective doses. Warn about next-day impairment and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Flurazepam?
MediHelp rates the interaction as moderate. Chlorpheniramine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sedating antihistamine with the long-acting benzodiazepine flurazepam increases drowsiness, dizziness and psychomotor impairment. Because the active metabolite of flurazepam persists, effects may last into the next day, with higher fall risk in older adults.
How serious is the interaction between Chlorpheniramine and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially in elderly patients, or use the lowest effective doses. Warn about next-day impairment and driving.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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