Drug interactions
Chlorpheniramine + Glycopyrronium tosylate
Severity: Moderate
Chlorpheniramine and Glycopyrronium tosylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium tosylate is absorbed systemically to some degree and has anticholinergic effects. Chlorpheniramine is also anticholinergic, so dry mouth, blurred vision, constipation and urinary retention may be additive.
What this interaction means in plain words
Chlorpheniramine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive peripheral antimuscarinic effects of the two drugs.
What to do
Monitor for anticholinergic adverse effects such as urinary retention and blurred vision. Consider a non-sedating antihistamine if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Glycopyrronium tosylate?
MediHelp rates the interaction as moderate. Chlorpheniramine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical glycopyrronium tosylate is absorbed systemically to some degree and has anticholinergic effects. Chlorpheniramine is also anticholinergic, so dry mouth, blurred vision, constipation and urinary retention may be additive.
How serious is the interaction between Chlorpheniramine and Glycopyrronium tosylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as urinary retention and blurred vision. Consider a non-sedating antihistamine if symptoms develop.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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