Drug interactions
Chlorpheniramine + Lofepramine
Severity: Moderate
Chlorpheniramine and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with sedative and anticholinergic properties, and chlorpheniramine adds to both. Patients may have increased drowsiness, dry mouth, constipation, blurred vision and urinary retention.
What this interaction means in plain words
Chlorpheniramine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Monitor for oversedation and anticholinergic effects, particularly in older adults, and consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Lofepramine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with sedative and anticholinergic properties, and chlorpheniramine adds to both. Patients may have increased drowsiness, dry mouth, constipation, blurred vision and urinary retention.
How serious is the interaction between Chlorpheniramine and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, particularly in older adults, and consider a non-sedating antihistamine.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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