Drug interactions
Chlorpheniramine + Lormetazepam
Severity: Moderate
Chlorpheniramine and Lormetazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lormetazepam is a hypnotic benzodiazepine, and chlorpheniramine can add to its sedative and psychomotor-impairing effects. This raises the risk of next-day drowsiness, falls and accidents.
What this interaction means in plain words
Chlorpheniramine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation and H1 antagonism.
What to do
Avoid concurrent use where possible, especially in older adults, or use the lowest effective doses. Counsel on driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Lormetazepam?
MediHelp rates the interaction as moderate. Chlorpheniramine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lormetazepam is a hypnotic benzodiazepine, and chlorpheniramine can add to its sedative and psychomotor-impairing effects. This raises the risk of next-day drowsiness, falls and accidents.
How serious is the interaction between Chlorpheniramine and Lormetazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, especially in older adults, or use the lowest effective doses. Counsel on driving and fall risk.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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