Drug interactions
Chlorpheniramine + Loxapine inhaled
Severity: Moderate
Chlorpheniramine and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine can cause sedation and bronchospasm, and chlorpheniramine adds sedation and anticholinergic effects. The combination may cause excessive drowsiness and impaired alertness.
What this interaction means in plain words
Chlorpheniramine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine and histamine antagonism, with additive anticholinergic effects.
What to do
Monitor sedation level after inhaled loxapine and for anticholinergic effects. Consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Loxapine inhaled?
MediHelp rates the interaction as moderate. Chlorpheniramine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine can cause sedation and bronchospasm, and chlorpheniramine adds sedation and anticholinergic effects. The combination may cause excessive drowsiness and impaired alertness.
How serious is the interaction between Chlorpheniramine and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level after inhaled loxapine and for anticholinergic effects. Consider a non-sedating antihistamine.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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