Drug interactions
Chlorpheniramine + Meprobamate
Severity: Moderate
Chlorpheniramine and Meprobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic, and chlorpheniramine causes sedation. Combined use can deepen drowsiness, impair coordination and reduce psychomotor performance, particularly in older adults.
What this interaction means in plain words
Chlorpheniramine and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through H1-receptor blockade and GABA-A-mediated sedation.
What to do
Counsel patients to avoid driving and alcohol, and consider a non-sedating antihistamine. Reduce doses or monitor sedation closely in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpheniramine and Meprobamate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Meprobamate?
MediHelp rates the interaction as moderate. Chlorpheniramine and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative-anxiolytic, and chlorpheniramine causes sedation. Combined use can deepen drowsiness, impair coordination and reduce psychomotor performance, particularly in older adults.
How serious is the interaction between Chlorpheniramine and Meprobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and alcohol, and consider a non-sedating antihistamine. Reduce doses or monitor sedation closely in elderly patients.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
