Drug interactions
Chlorpheniramine + Metoclopramide intranasal
Severity: Moderate
Chlorpheniramine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sedating antihistamines can add to the drowsiness and CNS effects of metoclopramide. Their anticholinergic activity may also oppose metoclopramide's prokinetic action on gastric motility.
What this interaction means in plain words
Chlorpheniramine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and pharmacodynamic antagonism of prokinetic effect by anticholinergic activity.
What to do
Counsel patients about drowsiness and avoid driving until response is known. Reassess the need for the antihistamine if gastroparesis symptoms do not improve.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Chlorpheniramine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sedating antihistamines can add to the drowsiness and CNS effects of metoclopramide. Their anticholinergic activity may also oppose metoclopramide's prokinetic action on gastric motility.
How serious is the interaction between Chlorpheniramine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and avoid driving until response is known. Reassess the need for the antihistamine if gastroparesis symptoms do not improve.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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