Drug interactions
Chlorpheniramine + Midazolam intranasal
Severity: Major
Chlorpheniramine and Midazolam intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sedating antihistamines can add to the CNS and respiratory depressant effects of midazolam. This may produce deeper or prolonged sedation, hypoventilation or apnea.
What this interaction means in plain words
Chlorpheniramine and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via GABA-A potentiation and H1 antagonism.
What to do
Avoid co-use when possible; if needed, reduce the midazolam dose and monitor respiratory rate and oxygen saturation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Midazolam intranasal?
MediHelp rates the interaction as major. Chlorpheniramine and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sedating antihistamines can add to the CNS and respiratory depressant effects of midazolam. This may produce deeper or prolonged sedation, hypoventilation or apnea.
How serious is the interaction between Chlorpheniramine and Midazolam intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-use when possible; if needed, reduce the midazolam dose and monitor respiratory rate and oxygen saturation.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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