Drug interactions
Chlorpheniramine + Passion flower
Severity: Minor
Chlorpheniramine and Passion flower: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passion flower has mild sedative and anxiolytic effects and may add to the drowsiness of chlorpheniramine. Clinical data are limited.
What this interaction means in plain words
Chlorpheniramine and Passion flower have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive CNS depression, possibly via GABAergic activity.
What to do
Advise patients to monitor for excessive drowsiness and avoid driving if impaired. Stop the herbal product if sedation is problematic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Passion flower?
MediHelp rates the interaction as minor. Chlorpheniramine and Passion flower have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Passion flower has mild sedative and anxiolytic effects and may add to the drowsiness of chlorpheniramine. Clinical data are limited.
How serious is the interaction between Chlorpheniramine and Passion flower?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to monitor for excessive drowsiness and avoid driving if impaired. Stop the herbal product if sedation is problematic.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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