Drug interactions
Chlorpheniramine + Pimozide
Severity: Moderate
Chlorpheniramine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating antihistamine with anticholinergic properties. With pimozide it may cause additive drowsiness, impaired psychomotor performance and anticholinergic effects.
What this interaction means in plain words
Chlorpheniramine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Prefer a non-sedating antihistamine. If combined, monitor for sedation and anticholinergic effects and warn about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Pimozide?
MediHelp rates the interaction as moderate. Chlorpheniramine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating antihistamine with anticholinergic properties. With pimozide it may cause additive drowsiness, impaired psychomotor performance and anticholinergic effects.
How serious is the interaction between Chlorpheniramine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine. If combined, monitor for sedation and anticholinergic effects and warn about driving.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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