Drug interactions
Chlorpheniramine + Quazepam
Severity: Moderate
Chlorpheniramine and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a benzodiazepine hypnotic, and chlorpheniramine adds sedation. The combination can increase drowsiness, impair coordination and psychomotor skills, and raise fall risk.
What this interaction means in plain words
Chlorpheniramine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and H1 antagonism.
What to do
Avoid driving and alcohol, and consider a non-sedating antihistamine. Monitor older adults closely for oversedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Quazepam?
MediHelp rates the interaction as moderate. Chlorpheniramine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a benzodiazepine hypnotic, and chlorpheniramine adds sedation. The combination can increase drowsiness, impair coordination and psychomotor skills, and raise fall risk.
How serious is the interaction between Chlorpheniramine and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid driving and alcohol, and consider a non-sedating antihistamine. Monitor older adults closely for oversedation and falls.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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