Drug interactions
Chlorpheniramine + Triclofos
Severity: Moderate
Chlorpheniramine and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic prodrug of trichloroethanol, and combining it with chlorpheniramine increases drowsiness and psychomotor impairment. Excess sedation is more likely in children and older adults.
What this interaction means in plain words
Chlorpheniramine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from trichloroethanol GABA-A potentiation and antihistamine H1 blockade.
What to do
Use the lowest effective doses and monitor sedation, particularly in children and the elderly. Avoid driving or hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Triclofos?
MediHelp rates the interaction as moderate. Chlorpheniramine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic prodrug of trichloroethanol, and combining it with chlorpheniramine increases drowsiness and psychomotor impairment. Excess sedation is more likely in children and older adults.
How serious is the interaction between Chlorpheniramine and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, particularly in children and the elderly. Avoid driving or hazardous activities.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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