Drug interactions
Chlorpheniramine + Valerian
Severity: Moderate
Chlorpheniramine and Valerian: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has sedative properties and may add to the drowsiness caused by chlorpheniramine. This can impair alertness and coordination.
What this interaction means in plain words
Chlorpheniramine and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with valerian thought to act via GABAergic mechanisms.
What to do
Advise caution with driving and machinery, and stop or reduce valerian if daytime drowsiness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Valerian?
MediHelp rates the interaction as moderate. Chlorpheniramine and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valerian has sedative properties and may add to the drowsiness caused by chlorpheniramine. This can impair alertness and coordination.
How serious is the interaction between Chlorpheniramine and Valerian?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise caution with driving and machinery, and stop or reduce valerian if daytime drowsiness develops.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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