Drug interactions
Chlorpheniramine + Yohimbine
Severity: Minor
Chlorpheniramine and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is a stimulating alpha-2 antagonist that may partly offset the sedation of chlorpheniramine. The net effect is unpredictable, and no significant clinical harm is established.
What this interaction means in plain words
Chlorpheniramine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects: central alpha-2 blockade and noradrenergic stimulation versus H1 antagonism.
What to do
No specific action is required; monitor for variable sedation or anxiety and adjust therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Yohimbine?
MediHelp rates the interaction as minor. Chlorpheniramine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbine is a stimulating alpha-2 antagonist that may partly offset the sedation of chlorpheniramine. The net effect is unpredictable, and no significant clinical harm is established.
How serious is the interaction between Chlorpheniramine and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; monitor for variable sedation or anxiety and adjust therapy as needed.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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