Drug interactions
Chlorpropamide + Chlorthalidone
Severity: Moderate
Chlorpropamide and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics can raise blood glucose and reduce the effect of sulfonylureas, so glycemic control may worsen. Chlorpropamide also carries a risk of hyponatremia, which can add to thiazide-related sodium loss. The combination may call for adjusting diabetes therapy.
What this interaction means in plain words
Chlorpropamide and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Chlorthalidone belongs to Cardiovascular.
Why it happens
Thiazides impair insulin secretion and peripheral glucose utilization, opposing the hypoglycemic action; additive hyponatremia risk with chlorpropamide.
What to do
Monitor blood glucose and serum sodium after starting or changing chlorthalidone, and increase the antidiabetic dose if needed. Consider a different sulfonylurea in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Chlorthalidone?
MediHelp rates the interaction as moderate. Chlorpropamide and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-type diuretics can raise blood glucose and reduce the effect of sulfonylureas, so glycemic control may worsen. Chlorpropamide also carries a risk of hyponatremia, which can add to thiazide-related sodium loss. The combination may call for adjusting diabetes therapy.
How serious is the interaction between Chlorpropamide and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium after starting or changing chlorthalidone, and increase the antidiabetic dose if needed. Consider a different sulfonylurea in older patients.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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