Drug interactions
Chlorpropamide + Clozapine
Severity: Moderate
Chlorpropamide and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine can cause hyperglycemia and insulin resistance, which may reduce the effectiveness of chlorpropamide. Glycemic control may worsen after clozapine is started or the dose is increased.
What this interaction means in plain words
Chlorpropamide and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Clozapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism, as clozapine impairs glucose tolerance and insulin sensitivity.
What to do
Monitor blood glucose and HbA1c regularly and adjust the antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Clozapine?
MediHelp rates the interaction as moderate. Chlorpropamide and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine can cause hyperglycemia and insulin resistance, which may reduce the effectiveness of chlorpropamide. Glycemic control may worsen after clozapine is started or the dose is increased.
How serious is the interaction between Chlorpropamide and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly and adjust the antidiabetic therapy as needed.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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