Drug interactions
Chlorpropamide + Deflazacort
Severity: Moderate
Chlorpropamide and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a glucocorticoid that can raise blood glucose and so oppose the effect of chlorpropamide. Glycemic control may worsen, especially with prolonged or higher-dose use.
What this interaction means in plain words
Chlorpropamide and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Deflazacort belongs to Miscellaneous.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose output antagonize sulfonylurea action.
What to do
Monitor blood glucose during corticosteroid therapy and increase chlorpropamide or adjust therapy as needed. Reduce the antidiabetic dose again when the steroid is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Chlorpropamide with Deflazacort?
MediHelp rates the interaction as moderate. Chlorpropamide and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort is a glucocorticoid that can raise blood glucose and so oppose the effect of chlorpropamide. Glycemic control may worsen, especially with prolonged or higher-dose use.
How serious is the interaction between Chlorpropamide and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during corticosteroid therapy and increase chlorpropamide or adjust therapy as needed. Reduce the antidiabetic dose again when the steroid is withdrawn.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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