Drug interactions
Chlorpropamide + Dulaglutide
Severity: Moderate
Chlorpropamide and Dulaglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide increases glucose-dependent insulin secretion, and with a sulfonylurea it raises the risk of hypoglycemia. Chlorpropamide's long half-life can prolong any episodes.
What this interaction means in plain words
Chlorpropamide and Dulaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Dulaglutide belongs to Endocrine.
Why it happens
Additive insulinotropic effects of GLP-1 receptor agonism and sulfonylurea-mediated insulin release.
What to do
Consider lowering the chlorpropamide dose when dulaglutide is started and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Dulaglutide
Frequently asked questions
Can I take Chlorpropamide with Dulaglutide?
MediHelp rates the interaction as moderate. Chlorpropamide and Dulaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide increases glucose-dependent insulin secretion, and with a sulfonylurea it raises the risk of hypoglycemia. Chlorpropamide's long half-life can prolong any episodes.
How serious is the interaction between Chlorpropamide and Dulaglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the chlorpropamide dose when dulaglutide is started and monitor blood glucose.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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