Drug interactions
Chlorpropamide + Empagliflozin-metformin
Severity: Moderate
Chlorpropamide and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an SGLT2 inhibitor to a sulfonylurea increases the risk of hypoglycemia. Chlorpropamide has a long half-life, so low glucose may be prolonged.
What this interaction means in plain words
Chlorpropamide and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin secretion stimulation by the sulfonylurea and urinary glucose excretion by empagliflozin.
What to do
Consider reducing the sulfonylurea dose when starting empagliflozin and counsel the patient on hypoglycemia symptoms and blood glucose monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Chlorpropamide and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an SGLT2 inhibitor to a sulfonylurea increases the risk of hypoglycemia. Chlorpropamide has a long half-life, so low glucose may be prolonged.
How serious is the interaction between Chlorpropamide and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the sulfonylurea dose when starting empagliflozin and counsel the patient on hypoglycemia symptoms and blood glucose monitoring.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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