Drug interactions
Chlorpropamide + Eprosartan-hydrochlorothiazide
Severity: Moderate
Chlorpropamide and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and may weaken the glucose-lowering effect of chlorpropamide. Both drugs can also cause hyponatremia, and chlorpropamide is long-acting, so electrolyte disturbances may be prolonged.
What this interaction means in plain words
Chlorpropamide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism from thiazide-induced hyperglycemia, with additive effects on sodium handling.
What to do
Monitor blood glucose and serum sodium after starting or adjusting the thiazide, and adjust the antidiabetic dose or consider an alternative agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Chlorpropamide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can raise blood glucose and may weaken the glucose-lowering effect of chlorpropamide. Both drugs can also cause hyponatremia, and chlorpropamide is long-acting, so electrolyte disturbances may be prolonged.
How serious is the interaction between Chlorpropamide and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium after starting or adjusting the thiazide, and adjust the antidiabetic dose or consider an alternative agent.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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