Drug interactions
Chlorpropamide + Fludrocortisone
Severity: Minor
Chlorpropamide and Fludrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has mild glucocorticoid activity that may raise blood glucose and reduce chlorpropamide's effect. The impact at typical doses is usually small but may matter in unstable diabetes.
What this interaction means in plain words
Chlorpropamide and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Fludrocortisone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: corticosteroid-induced insulin resistance and increased hepatic glucose output.
What to do
Monitor blood glucose when fludrocortisone is started or its dose changed. Adjust chlorpropamide if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Fludrocortisone?
MediHelp rates the interaction as minor. Chlorpropamide and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fludrocortisone has mild glucocorticoid activity that may raise blood glucose and reduce chlorpropamide's effect. The impact at typical doses is usually small but may matter in unstable diabetes.
How serious is the interaction between Chlorpropamide and Fludrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fludrocortisone is started or its dose changed. Adjust chlorpropamide if needed.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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