Drug interactions
Chlorpropamide + Flurbiprofen
Severity: Moderate
Chlorpropamide and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas, increasing the risk of hypoglycemia. Chlorpropamide has a long half-life, so episodes may be prolonged, especially in older patients or those with renal impairment.
What this interaction means in plain words
Chlorpropamide and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma protein binding and reduced renal clearance of the sulfonylurea; the mechanism is not fully established.
What to do
Monitor blood glucose when starting or stopping flurbiprofen and counsel on hypoglycemia symptoms. Reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Flurbiprofen?
MediHelp rates the interaction as moderate. Chlorpropamide and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas, increasing the risk of hypoglycemia. Chlorpropamide has a long half-life, so episodes may be prolonged, especially in older patients or those with renal impairment.
How serious is the interaction between Chlorpropamide and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping flurbiprofen and counsel on hypoglycemia symptoms. Reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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