Drug interactions
Chlorpropamide + Fosinopril
Severity: Moderate
Chlorpropamide and Fosinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase insulin sensitivity and enhance the effect of chlorpropamide. Hypoglycemia may be more frequent, and chlorpropamide's long half-life can prolong episodes.
What this interaction means in plain words
Chlorpropamide and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Fosinopril belongs to Cardiovascular.
Why it happens
ACE inhibition increases bradykinin and improves insulin sensitivity, adding to sulfonylurea-induced insulin secretion.
What to do
Monitor blood glucose when fosinopril is started or changed. Reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Fosinopril?
MediHelp rates the interaction as moderate. Chlorpropamide and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may increase insulin sensitivity and enhance the effect of chlorpropamide. Hypoglycemia may be more frequent, and chlorpropamide's long half-life can prolong episodes.
How serious is the interaction between Chlorpropamide and Fosinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fosinopril is started or changed. Reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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