Drug interactions
Chlorpropamide + Hydrochlorothiazide-telmisartan
Severity: Moderate
Chlorpropamide and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and may reduce the effectiveness of sulfonylureas such as chlorpropamide. Thiazide-induced hyponatremia may also add to the SIADH-like effect of chlorpropamide.
What this interaction means in plain words
Chlorpropamide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Thiazide-induced impairment of insulin secretion and sensitivity opposes sulfonylurea action, and both drugs can lower sodium.
What to do
Monitor blood glucose and serum sodium, and adjust the antidiabetic regimen if control worsens. Consider a different sulfonylurea in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Chlorpropamide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can raise blood glucose and may reduce the effectiveness of sulfonylureas such as chlorpropamide. Thiazide-induced hyponatremia may also add to the SIADH-like effect of chlorpropamide.
How serious is the interaction between Chlorpropamide and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium, and adjust the antidiabetic regimen if control worsens. Consider a different sulfonylurea in older patients.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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