Drug interactions
Chlorpropamide + Hydrochlorothiazide-valsartan
Severity: Moderate
Chlorpropamide and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and so reduce the effectiveness of sulfonylureas such as chlorpropamide. Thiazides may also contribute to hyponatremia, which chlorpropamide itself can cause through increased antidiuretic hormone effect.
What this interaction means in plain words
Chlorpropamide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Thiazide-induced hyperglycemia opposes sulfonylurea action, and both agents can lower serum sodium.
What to do
Monitor blood glucose and serum sodium after starting or changing the thiazide. Adjust the antidiabetic regimen or consider an alternative sulfonylurea if control is lost or hyponatremia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Chlorpropamide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can raise blood glucose and so reduce the effectiveness of sulfonylureas such as chlorpropamide. Thiazides may also contribute to hyponatremia, which chlorpropamide itself can cause through increased antidiuretic hormone effect.
How serious is the interaction between Chlorpropamide and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium after starting or changing the thiazide. Adjust the antidiabetic regimen or consider an alternative sulfonylurea if control is lost or hyponatremia occurs.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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