Drug interactions
Chlorpropamide + Ibuprofen
Severity: Moderate
Chlorpropamide and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide, increasing the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged.
What this interaction means in plain words
Chlorpropamide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Ibuprofen belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma protein binding and reduced renal clearance, with prostaglandin-related effects on insulin secretion; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping ibuprofen and teach the patient to recognize hypoglycemia. Reduce the sulfonylurea dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Ibuprofen?
MediHelp rates the interaction as moderate. Chlorpropamide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen may enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide, increasing the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged.
How serious is the interaction between Chlorpropamide and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping ibuprofen and teach the patient to recognize hypoglycemia. Reduce the sulfonylurea dose if glucose falls.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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