Drug interactions
Chlorpropamide + Insulin isophane protamine human
Severity: Moderate
Chlorpropamide and Insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpropamide stimulates insulin secretion while NPH insulin supplies exogenous insulin, so together they lower blood glucose more than either alone. Hypoglycemia can be prolonged because chlorpropamide has a very long half-life, especially in older adults or those with renal impairment.
What this interaction means in plain words
Chlorpropamide and Insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Insulin isophane protamine human belongs to Endocrine.
Why it happens
Additive glucose-lowering effect from exogenous insulin plus sulfonylurea-induced endogenous insulin release.
What to do
Monitor blood glucose closely and reduce the insulin or sulfonylurea dose when starting the combination. Educate the patient on recognizing and treating hypoglycemia, and consider a shorter-acting agent in older or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpropamide and Insulin isophane protamine human, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Insulin isophane protamine human?
MediHelp rates the interaction as moderate. Chlorpropamide and Insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpropamide stimulates insulin secretion while NPH insulin supplies exogenous insulin, so together they lower blood glucose more than either alone. Hypoglycemia can be prolonged because chlorpropamide has a very long half-life, especially in older adults or those with renal impairment.
How serious is the interaction between Chlorpropamide and Insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the insulin or sulfonylurea dose when starting the combination. Educate the patient on recognizing and treating hypoglycemia, and consider a shorter-acting agent in older or renally impaired patients.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
