Drug interactions
Chlorpropamide + Ivosidenib
Severity: Moderate
Chlorpropamide and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can induce CYP2C9, which may lower chlorpropamide concentrations. Loss of glucose-lowering effect and worsened glycemic control may result.
What this interaction means in plain words
Chlorpropamide and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP2C9, increasing metabolism of chlorpropamide.
What to do
Monitor blood glucose closely when ivosidenib is started or stopped. Increase chlorpropamide dose or choose an alternative antidiabetic if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Chlorpropamide with Ivosidenib?
MediHelp rates the interaction as moderate. Chlorpropamide and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib can induce CYP2C9, which may lower chlorpropamide concentrations. Loss of glucose-lowering effect and worsened glycemic control may result.
How serious is the interaction between Chlorpropamide and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when ivosidenib is started or stopped. Increase chlorpropamide dose or choose an alternative antidiabetic if control is lost.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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