Drug interactions
Chlorpropamide + Meclofenamic acid
Severity: Moderate
Chlorpropamide and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas, raising the chance of hypoglycemia. Chlorpropamide has a long half-life, so episodes can be prolonged, particularly in elderly patients or those with renal impairment.
What this interaction means in plain words
Chlorpropamide and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Possible displacement of the sulfonylurea from plasma protein binding and reduced renal clearance; the mechanism is not fully established.
What to do
Monitor blood glucose when the NSAID is started or stopped and counsel patients on hypoglycemia symptoms. Reduce the sulfonylurea dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Meclofenamic acid?
MediHelp rates the interaction as moderate. Chlorpropamide and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas, raising the chance of hypoglycemia. Chlorpropamide has a long half-life, so episodes can be prolonged, particularly in elderly patients or those with renal impairment.
How serious is the interaction between Chlorpropamide and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the NSAID is started or stopped and counsel patients on hypoglycemia symptoms. Reduce the sulfonylurea dose if glucose falls.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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