Drug interactions
Chlorpropamide + Meloxicam
Severity: Moderate
Chlorpropamide and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas and increase the risk of hypoglycemia. The effect is expected to be modest for meloxicam but chlorpropamide has a long half-life.
What this interaction means in plain words
Chlorpropamide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Meloxicam belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma protein binding and reduced renal clearance of the sulfonylurea; CYP2C9 competition may also contribute.
What to do
Monitor blood glucose when starting or stopping meloxicam and counsel on hypoglycemia symptoms. Reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpropamide and Meloxicam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Meloxicam?
MediHelp rates the interaction as moderate. Chlorpropamide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas and increase the risk of hypoglycemia. The effect is expected to be modest for meloxicam but chlorpropamide has a long half-life.
How serious is the interaction between Chlorpropamide and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping meloxicam and counsel on hypoglycemia symptoms. Reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
