Drug interactions
Chlorpropamide + Moexipril
Severity: Moderate
Chlorpropamide and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance the glucose-lowering effect of sulfonylureas, raising the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged.
What this interaction means in plain words
Chlorpropamide and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Moexipril belongs to Cardiovascular.
Why it happens
Pharmacodynamic synergism: improved insulin sensitivity with ACE inhibition adds to sulfonylurea insulin secretion.
What to do
Monitor blood glucose, especially in the first weeks of combined therapy and in renal impairment. Lower the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Moexipril?
MediHelp rates the interaction as moderate. Chlorpropamide and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance the glucose-lowering effect of sulfonylureas, raising the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged.
How serious is the interaction between Chlorpropamide and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, especially in the first weeks of combined therapy and in renal impairment. Lower the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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