Drug interactions
Chlorpropamide + Naproxen
Severity: Moderate
Chlorpropamide and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen may enhance the glucose-lowering effect of chlorpropamide and increase hypoglycemia risk. Chlorpropamide is long-acting and renally cleared, so low blood sugar can be prolonged.
What this interaction means in plain words
Chlorpropamide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Naproxen belongs to Musculoskeletal.
Why it happens
Probable displacement from protein binding and reduced renal clearance of the sulfonylurea; the mechanism is not fully established.
What to do
Monitor blood glucose when naproxen is started or stopped and counsel the patient on hypoglycemia symptoms. Reduce the sulfonylurea dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Naproxen?
MediHelp rates the interaction as moderate. Chlorpropamide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen may enhance the glucose-lowering effect of chlorpropamide and increase hypoglycemia risk. Chlorpropamide is long-acting and renally cleared, so low blood sugar can be prolonged.
How serious is the interaction between Chlorpropamide and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when naproxen is started or stopped and counsel the patient on hypoglycemia symptoms. Reduce the sulfonylurea dose if needed.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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