Drug interactions
Chlorpropamide + Rifabutin
Severity: Minor
Chlorpropamide and Rifabutin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces hepatic enzymes and may reduce sulfonylurea exposure, with potential loss of glycemic control. The effect is less marked than with rifampicin, and chlorpropamide is largely excreted unchanged, so the impact is likely limited.
What this interaction means in plain words
Chlorpropamide and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induction of hepatic metabolizing enzymes may increase chlorpropamide metabolism.
What to do
Monitor blood glucose after starting or stopping rifabutin and adjust the chlorpropamide dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpropamide
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Chlorpropamide with Rifabutin?
MediHelp rates the interaction as minor. Chlorpropamide and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifabutin induces hepatic enzymes and may reduce sulfonylurea exposure, with potential loss of glycemic control. The effect is less marked than with rifampicin, and chlorpropamide is largely excreted unchanged, so the impact is likely limited.
How serious is the interaction between Chlorpropamide and Rifabutin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping rifabutin and adjust the chlorpropamide dose if control changes.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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