Drug interactions
Chlorpropamide + Sulphasalazine
Severity: Moderate
Chlorpropamide and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine contains a sulfonamide-type moiety, and sulfonamide antibacterials are known to potentiate sulfonylurea hypoglycemia. Reports with sulfasalazine are sparse, but an enhanced glucose-lowering effect of chlorpropamide is plausible, and chlorpropamide's long half-life makes prolonged hypoglycemia a concern.
What this interaction means in plain words
Chlorpropamide and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Possible displacement from plasma protein binding and/or reduced sulfonylurea clearance; the mechanism is not well established for sulfasalazine.
What to do
Monitor blood glucose more frequently when sulfasalazine is started or stopped in patients on chlorpropamide. Reduce the sulfonylurea dose if hypoglycemia occurs and counsel the patient on its symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Sulphasalazine?
MediHelp rates the interaction as moderate. Chlorpropamide and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfasalazine contains a sulfonamide-type moiety, and sulfonamide antibacterials are known to potentiate sulfonylurea hypoglycemia. Reports with sulfasalazine are sparse, but an enhanced glucose-lowering effect of chlorpropamide is plausible, and chlorpropamide's long half-life makes prolonged hypoglycemia a concern.
How serious is the interaction between Chlorpropamide and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when sulfasalazine is started or stopped in patients on chlorpropamide. Reduce the sulfonylurea dose if hypoglycemia occurs and counsel the patient on its symptoms.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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