Drug interactions
Chlorpropamide + Tolmetin
Severity: Moderate
Chlorpropamide and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin may enhance the glucose-lowering effect of chlorpropamide, and hypoglycemia may occur in some patients. Chlorpropamide's long half-life makes any episode prolonged.
What this interaction means in plain words
Chlorpropamide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Tolmetin belongs to Musculoskeletal.
Why it happens
The mechanism is not firmly established; protein-binding displacement and prostaglandin effects on insulin secretion have been proposed.
What to do
Monitor blood glucose when tolmetin is started or stopped, and lower the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Tolmetin?
MediHelp rates the interaction as moderate. Chlorpropamide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolmetin may enhance the glucose-lowering effect of chlorpropamide, and hypoglycemia may occur in some patients. Chlorpropamide's long half-life makes any episode prolonged.
How serious is the interaction between Chlorpropamide and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when tolmetin is started or stopped, and lower the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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