Drug interactions
Chlorpropamide + Triamcinolone
Severity: Moderate
Chlorpropamide and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose and can offset the glucose-lowering effect of sulfonylureas. Diabetic control may deteriorate, and glucose may then drop when the steroid is stopped.
What this interaction means in plain words
Chlorpropamide and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Triamcinolone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through corticosteroid-induced gluconeogenesis and insulin resistance.
What to do
Monitor blood glucose closely during and after steroid therapy. Increase the antidiabetic dose as needed and reduce it again when the steroid is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Triamcinolone?
MediHelp rates the interaction as moderate. Chlorpropamide and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids raise blood glucose and can offset the glucose-lowering effect of sulfonylureas. Diabetic control may deteriorate, and glucose may then drop when the steroid is stopped.
How serious is the interaction between Chlorpropamide and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and after steroid therapy. Increase the antidiabetic dose as needed and reduce it again when the steroid is withdrawn.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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