Drug interactions
Chlorthalidone + Deflazacort
Severity: Moderate
Chlorthalidone and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, so combined use increases the risk of hypokalemia. This is important in patients with heart disease or those taking other QT-prolonging or arrhythmogenic drugs.
What this interaction means in plain words
Chlorthalidone and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Deflazacort belongs to Miscellaneous.
Why it happens
Additive urinary potassium loss from thiazide-type diuresis and glucocorticoid mineralocorticoid activity.
What to do
Monitor serum potassium regularly and supplement if needed. Consider checking magnesium as well.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Chlorthalidone with Deflazacort?
MediHelp rates the interaction as moderate. Chlorthalidone and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, so combined use increases the risk of hypokalemia. This is important in patients with heart disease or those taking other QT-prolonging or arrhythmogenic drugs.
How serious is the interaction between Chlorthalidone and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and supplement if needed. Consider checking magnesium as well.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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