Drug interactions
Chlorthalidone + Drospirenone
Severity: Moderate
Chlorthalidone and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, whereas chlorthalidone lowers it. The net effect is unpredictable, and hyperkalemia is possible in patients with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Chlorthalidone and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Opposing potassium effects: drospirenone's aldosterone antagonism reduces potassium excretion, while chlorthalidone increases renal potassium loss.
What to do
Check serum potassium during the first treatment cycle and periodically thereafter. Avoid adding other potassium-raising agents without monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Drospirenone
Frequently asked questions
Can I take Chlorthalidone with Drospirenone?
MediHelp rates the interaction as moderate. Chlorthalidone and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, whereas chlorthalidone lowers it. The net effect is unpredictable, and hyperkalemia is possible in patients with renal impairment or other potassium-raising drugs.
How serious is the interaction between Chlorthalidone and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first treatment cycle and periodically thereafter. Avoid adding other potassium-raising agents without monitoring.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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