Drug interactions
Chlorthalidone + Empagliflozin-metformin
Severity: Moderate
Chlorthalidone and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin and chlorthalidone both promote fluid and sodium loss, increasing the risk of volume depletion, hypotension and kidney injury. Thiazide-type diuretics can also raise blood glucose, partly offsetting antidiabetic effect.
What this interaction means in plain words
Chlorthalidone and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Additive diuretic and natriuretic effects, plus thiazide-related impairment of glucose tolerance.
What to do
Monitor blood pressure, volume status, electrolytes, renal function and glucose, and reduce the diuretic dose if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Chlorthalidone and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin and chlorthalidone both promote fluid and sodium loss, increasing the risk of volume depletion, hypotension and kidney injury. Thiazide-type diuretics can also raise blood glucose, partly offsetting antidiabetic effect.
How serious is the interaction between Chlorthalidone and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, electrolytes, renal function and glucose, and reduce the diuretic dose if volume depletion occurs.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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