Drug interactions
Chlorthalidone + Epoprostenol
Severity: Moderate
Chlorthalidone and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator, and with chlorthalidone it may produce additive blood pressure lowering. Diuretic-related volume depletion can increase the risk of symptomatic hypotension.
What this interaction means in plain words
Chlorthalidone and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Epoprostenol belongs to Genitourinary.
Why it happens
Additive hypotensive effects from vasodilation and diuretic-induced volume reduction.
What to do
Monitor blood pressure and volume status when starting or titrating either drug. Reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Chlorthalidone with Epoprostenol?
MediHelp rates the interaction as moderate. Chlorthalidone and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent vasodilator, and with chlorthalidone it may produce additive blood pressure lowering. Diuretic-related volume depletion can increase the risk of symptomatic hypotension.
How serious is the interaction between Chlorthalidone and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status when starting or titrating either drug. Reduce doses if symptomatic hypotension occurs.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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