Drug interactions
Chlorthalidone + Eprosartan
Severity: Minor
Chlorthalidone and Eprosartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination gives additive blood pressure reduction and eprosartan tends to counter thiazide-induced hypokalemia. Volume depletion may cause hypotension or a fall in renal function.
What this interaction means in plain words
Chlorthalidone and Eprosartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorthalidone belongs to Cardiovascular; Eprosartan belongs to Cardiovascular.
Why it happens
Thiazide natriuresis combined with angiotensin receptor blockade, which reduces aldosterone-mediated potassium loss.
What to do
Monitor blood pressure, potassium and creatinine after starting or adjusting doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorthalidone
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Chlorthalidone with Eprosartan?
MediHelp rates the interaction as minor. Chlorthalidone and Eprosartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The combination gives additive blood pressure reduction and eprosartan tends to counter thiazide-induced hypokalemia. Volume depletion may cause hypotension or a fall in renal function.
How serious is the interaction between Chlorthalidone and Eprosartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and creatinine after starting or adjusting doses.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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