Drug interactions
Chlorthalidone + Flurbiprofen
Severity: Moderate
Chlorthalidone and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive effect of thiazide-type diuretics and cause fluid retention. Together they raise the risk of renal impairment, especially with volume depletion.
What this interaction means in plain words
Chlorthalidone and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, opposing diuretic action.
What to do
Monitor blood pressure, edema and renal function, and adjust antihypertensive therapy if control is lost. Ensure adequate hydration and limit NSAID duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Flurbiprofen?
MediHelp rates the interaction as moderate. Chlorthalidone and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive effect of thiazide-type diuretics and cause fluid retention. Together they raise the risk of renal impairment, especially with volume depletion.
How serious is the interaction between Chlorthalidone and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and renal function, and adjust antihypertensive therapy if control is lost. Ensure adequate hydration and limit NSAID duration.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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