Drug interactions
Chlorthalidone + Fluticasone-salmeterol
Severity: Moderate
Chlorthalidone and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone and salmeterol can both lower serum potassium, so combined use may cause clinically relevant hypokalemia and raise arrhythmia risk, particularly with high beta-agonist doses.
What this interaction means in plain words
Chlorthalidone and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive hypokalemia from diuretic renal potassium loss and beta-2 agonist intracellular potassium shift.
What to do
Monitor serum potassium and magnesium periodically and replace as needed, especially in patients with heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Chlorthalidone and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone and salmeterol can both lower serum potassium, so combined use may cause clinically relevant hypokalemia and raise arrhythmia risk, particularly with high beta-agonist doses.
How serious is the interaction between Chlorthalidone and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically and replace as needed, especially in patients with heart disease.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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